PPM1D Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52172-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52172-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52172-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52172-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
PPM1D
Background:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.5 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:300, ELISA 1:2000-1:5000
Immunogen:
Fusion protein of human PPM1D
Purification method:
Antigen affinity purification
Target Synonym:
EC 3.1.3.16;p53 induced protein phosphatase 1;p53-induced protein phosphatase 1;PP2C delta;PP2C-delta;PP2CD;Ppm1d;PPM1D;Protein phosphatase 1D;protein phosphatase 1D magnesium-dependent delta isoform ;Protein phosphatase 2C delta isoform;Protein phosphatase 2C isoform delta;Protein phosphatase magnesium dependent 1 delta;Protein phosphatase magnesium-dependent 1 delta;Protein phosphatase Mg2+/Mn2+ dependent 1D;Protein phosphatase Wip1;Wild type p53 induced phosphatase 1;WIP 1;WIP1
UNIProt ID:
O15297