DOK3 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52149-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52149-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52149-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52149-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
DOK3
Background:
DOK3 gene maps to chromosome 5q35.3. Dok3 was tyrosine phosphorylated by Src family members Lck, Fyn, and Lyn. Immunoprecipitation studies showed that Dok3 bound inhibitors SHIP and Csk but did not bind RasGAP. Dok3 binding to SHIP occurred via the SH2 domain. Dok3 also bound Csk via the Csk SH2 domain with possible involvement of the Csk SH3 domain as well.DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
53 kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, ELISA 1:1000-1:5000
Immunogen:
Fusion protein of human DOK3
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
Docking protein 3;DOK 3;DOK Like Protein;Dok3;DOK3;DOKL Pending;Downstream of tyrosine kinase 3;p62 DOK Like Protein
UNIProt ID:
Q7L591