MOB2 Polyclonal Antibody

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Elabscience
Product Code: E-AB-19976
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-19976-20uL20uL£125.00
Quantity:
E-AB-19976-60uL60uL£172.00
Quantity:
E-AB-19976-120uL120uL£237.00
Quantity:
E-AB-19976-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Immunohistochemistry of paraffin-embedded Human tonsil tissue using MOB2 Polyclonal Antibody at dilution of 1:40(?200)
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Immunohistochemistry of paraffin-embedded Human tonsil tissue using MOB2 Polyclonal Antibody at dilution of 1:40(?200)

Documents

Further Information

Abbreviation:
MOB2
Background:
MOB2 (Mps one binder kinase activator-like 2), also known as HCCA2 (Hepatocellular carcinoma-associated gene 2), is a 467 amino acid protein that belongs to the MOB1/phocein family. MOB2 is expressed in lung, spleen, brain, and fetal liver. It is highly expressed in hepatocellular carcinoma. MOB2 is localized in the perinuclear region of the cytoplasm in liver cancer tissues and colocalizes with MAD2L2 in the nucleus of Hela cells. MOB2 is characterized by two N-glycosylation sites, six N-myristolylation sites, two Src homology 3 (SH3), and several phosphorylation motifs which indicate that this protein may play a role in an intracellular signal transduction cascade. MOB2 binds to and regulates the autophosphorylation of the related human serine/threonine kinase 38 (NDR1) and serine/threonine kinase 38L(NDR2). It has been shown that MOB2 plays a critical role in cell cycle regulation. Overexpression of the protein during the G0/G1 phase inhibits cell proliferation causing cell cycle arrest. Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.08 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:40-1:200, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human MOB2
Purification method:
Antigen affinity purification
Target Synonym:
HCCA2;HCCA2 gene;HCCA2 protein;MOB kinase activator 2;MOB2;Mob2 homolog;MOB2 Mps One Binder homolog;MOB2;Mps one binder kinase activator like 2;Mps one binder kinase activator-like 2
UNIProt ID:
Q70IA6