IL12B Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-19816-20uL | 20uL | £125.00 |
Quantity:
| E-AB-19816-60uL | 60uL | £172.00 |
Quantity:
| E-AB-19816-120uL | 120uL | £237.00 |
Quantity:
| E-AB-19816-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
IL12B
Background:
Interleukin-12 (IL-12),is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit (IL-12A p35) and a 40 kDa subunit (IL-12B p40) that is secreted by a wide variety of antigen presenting cells (APCs),including phagocytes,B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis (MS),suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.32 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:40-1:200, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human IL12B
Purification method:
Antigen affinity purification
Target Synonym:
CLMF;CLMF p40;CLMF2;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL 12B;IL-12 subunit p40;IL-12B;IL12 p40;IL12B;IL12B;IMD28;IMD29;Interleukin 12 beta chain;Interleukin 12 p40;Interleukin-12 subunit beta;NK cell stimulatory factor chain 2;NKSF;NKSF2
UNIProt ID:
P29460