CORO2B Polyclonal Antibody

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Elabscience
Product Code: E-AB-19746
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-19746-20uL20uL£125.00
Quantity:
E-AB-19746-60uL60uL£172.00
Quantity:
E-AB-19746-120uL120uL£237.00
Quantity:
E-AB-19746-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western blot analysis of Mouse brain tissue NIH/3T3 cell lysates using CORO2B Polyclonal Antibody at dilution of 1:1000
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Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CORO2B Polyclonal Antibody at dilution of 1:50(?200)
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Western blot analysis of Mouse brain tissue NIH/3T3 cell lysates using CORO2B Polyclonal Antibody at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CORO2B Polyclonal Antibody at dilution of 1:50(?200)

Documents

Further Information

Abbreviation:
CORO2B
Background:
Coronins are a family of WD repeat-containing, actin-binding proteins that localize to submembraneous areas and regulate cell motility and cytoskeletal rearrangement. Coronin 1A (CORO1A, CLIPINA, CLABP, TACO, p57) can form coiled coil-mediated homotrimeric complexes that influence early phagosome formation. PKC-dependent phosphorylation of Coronin 1B (CORO1B) at Serine 2 regulates leading edge dynamics and cell motility in fibroblasts through interactions with Arp2/3 complex. Coronin 1C (CORO1C, Coronin 3, HCRNN4) is abundant in differentiating Neuro-2a cells, PC-12 cells and primary oligodendrocytes, where it is thought to influence neuron morphogenesis and migration. Coronin 2A (CORO2A, CLIPINB, IR10, WDR2) is a component of the approximately 1.5-2 megadalton N-CoR (nuclear receptor corepressor) complex of 10-12 proteins, which recruits HDACs to generate repressive chromatin. Coronin 7 (CORO7, CRN7) localizes to the Golgi membrane and influences the organization of intracellular membrane compartments and vesicular trafficking. Coronin 2B (CORO2B, CLIPINC) and Coronin 6 (CORO6) are similar to other members of this family, since they possess a conserved basic N-terminal motif and 3-10 WD repeats clustered in one to two core domains.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
55 kDa
Concentration:
1.5 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:5000, IHC 1:40-1:200, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human CORO2B
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
Actin binding protein;Clipin-C;CLIPINC;COR2B;CORO2B;Coronin actin binding protein 2B;Coronin;Coronin-2B;Coronin-like protein C;Protein FC96
UNIProt ID:
Q9UQ03