CEND1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-19691-20uL | 20uL | £125.00 |
Quantity:
| E-AB-19691-60uL | 60uL | £172.00 |
Quantity:
| E-AB-19691-120uL | 120uL | £237.00 |
Quantity:
| E-AB-19691-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
CEND1
Background:
BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
15 kDa
Concentration:
0.9 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human CEND1
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
BM88 ;BM88 antigen;Cell cycle exit and neuronal differentiation 1 ;Cell cycle exit and neuronal differentiation protein 1;FLJ90066;MGC34326
UNIProt ID:
Q8N111