C14orf169 Polyclonal Antibody

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Elabscience
Product Code: E-AB-19635
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-19635-20uL20uL£125.00
Quantity:
E-AB-19635-60uL60uL£172.00
Quantity:
E-AB-19635-120uL120uL£237.00
Quantity:
E-AB-19635-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using C14orf169 Polyclonal Antibody at dilution of 1:45(?200)
2 / 2
Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using C14orf169 Polyclonal Antibody at dilution of 1:45(?200)
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Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using C14orf169 Polyclonal Antibody at dilution of 1:45(?200)
Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using C14orf169 Polyclonal Antibody at dilution of 1:45(?200)

Documents

Further Information

Abbreviation:
C14orf169
Background:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.8 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human C14orf169
Purification method:
Antigen affinity purification
Target Synonym:
60S ribosomal protein L8 histidine hydroxylase;C14orf169;Chromosome 14 open reading frame 169 ;Histone lysine demethylase NO66;hsNO66;Hypothetical protein FLJ21802;Lysine-specific demethylase NO66;MAPJD;MYC associated protein with JmjC domain;NO66;NO66;Nucleolar protein 66;Ribosomal oxygenase NO66;ROX;Up regulated in lung cancer 2;URLC2
UNIProt ID:
Q9H6W3