CD274 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-19627-20uL | 20uL | £125.00 |
Quantity:
| E-AB-19627-60uL | 60uL | £172.00 |
Quantity:
| E-AB-19627-120uL | 120uL | £237.00 |
Quantity:
| E-AB-19627-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
CD274
Background:
Programmed cell death ligand 1(CD274,or B7-H1,PD-L1),is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors,the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell,and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal,essential for T-cell proliferation and production of IL10 and IFNG,in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa,the apparent molecular weight has been reported as 45-70 kDa,suggesting probable glycosylation .
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
33 kDa
Concentration:
0.72 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:100, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human CD274
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
B7 H;B7 H1;B7 homolog 1;B7-H1;B7H;B7H1;CD 274;CD274;CD274 antigen;CD274 molecule;MGC142294;MGC142296;OTTHUMP00000021029;PD L1;PD-L1;PD1L1;PDCD1 ligand 1;PDCD1L1;PDCD1LG1;PDL 1;PDL1;Programmed cell death 1 ligand 1;Programmed death ligand 1;RGD1566211
UNIProt ID:
Q9NZQ7