ATRX Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-19609-20uL | 20uL | £125.00 |
Quantity:
| E-AB-19609-60uL | 60uL | £172.00 |
Quantity:
| E-AB-19609-120uL | 120uL | £237.00 |
Quantity:
| E-AB-19609-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
ATRX
Background:
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.7 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human ATRX
Purification method:
Antigen affinity purification
Target Synonym:
Alpha thalassemia/mental retardation syndrome X linked homolog;ATP dependent helicase ATRX;ATP-dependent helicase ATRX;ATR2;Atrx;ATRX;DNA dependent ATPase and helicase;Helicase 2; X linked;MGC2094;MRXHF1;RAD54;RAD54L;SFM1;SHS;Transcriptional regulator ATRX;X linked helicase II;X linked nuclear protein;X-linked helicase II;X-linked nuclear protein;XH2;XNP;Znf HX;Znf-HX
UNIProt ID:
P46100