ZNHIT3 Polyclonal Antibody

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Elabscience
Product Code: E-AB-19558
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-19558-20uL20uL£125.00
Quantity:
E-AB-19558-60uL60uL£172.00
Quantity:
E-AB-19558-120uL120uL£237.00
Quantity:
E-AB-19558-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Immunohistochemistry of paraffin-embedded Human lung cancer tissue using ZNHIT3 Polyclonal Antibody at dilution of 1:80(?200)
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Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ZNHIT3 Polyclonal Antibody at dilution of 1:80(?200)
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Immunohistochemistry of paraffin-embedded Human lung cancer tissue using ZNHIT3 Polyclonal Antibody at dilution of 1:80(?200)
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ZNHIT3 Polyclonal Antibody at dilution of 1:80(?200)

Documents

Further Information

Abbreviation:
ZNHIT3
Background:
ZNHIT3 (zinc finger, HIT-type containing 3), also known as TRIP3 (thyroid receptor-interacting protein 3) or HNF-4a coactivator, is a 155 amino acid protein that contains one HIT-type zinc finger and regulates PPAR-mediated adipocyte differentiation. ZNHIT3 also coactivates HNF-4, and as a thyroid receptor interacting protein, ZNHIT3 interacts with the ligand binding domain of the thyroid receptor. The gene encoding ZNHIT3 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.9 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:40-1:250, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human ZNHIT3
Purification method:
Antigen affinity purification
Target Synonym:
HNF 4a coactivator ;Thyroid hormone receptor interactor 3;Thyroid receptor interacting protein 3;TR interacting protein 3;TRIP 3;TRIP3;Zinc finger HIT domain containing protein 3;Zinc finger HIT type 3;Zinc finger; HIT domain containing 3;Zinc finger; HIT type containing 3
UNIProt ID:
Q15649