GRM2 Polyclonal Antibody

GRM2

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

1.5 mg/mL

Unconjugated

IHC 1:50-1:300, ELISA 1:5000-1:10000

Synthetic peptide of human GRM2

Antigen affinity purification

AMPA selective glutamate receptor 2 ;GLUR2;GLURB;Glutamate metabotropic receptor 2;Glutamate receptor homolog;Glutamate receptor metabotropic 2;GPRC1B;GRM2;GRM2;Metabotropic glutamate receptor 2;mGlu2;mGluR2;OTTHUMP00000210984;OTTHUMP00000210986

Q14416