CUL4A Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-19279-20uL | 20uL | £125.00 |
Quantity:
| E-AB-19279-60uL | 60uL | £172.00 |
Quantity:
| E-AB-19279-120uL | 120uL | £237.00 |
Quantity:
| E-AB-19279-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
CUL4A
Background:
Cullin proteins assemble a large number of RING E3 ubiquitin ligases,participating in the proteolysis through the ubiquitin-proteasome pathway. Two cullin 4 (CUL4) proteins,CUL4A (87 kDa) and CUL4B(104 kDa),have been identified. The two CUL4 sequences are 83% identical. They target certain proteins for degradation by binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex with DDB. They form two individual E3 ligases,DDB1-CUL4ADDB2 and DDB1-CUL4BDDB2 in this process. CUL4A appeared in both the nucleus and the cytosol,suggesting a more complex mechanism for entering the nucleus. CUL4B is localized in the nucleus and facilitates the transfer of DDB1 into the nucleus independently of DDB2.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
88 kDa
Concentration:
1.62 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human CUL4A
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
2810470J21Rik;AW495282;CUL 4A;CUL-4A;Cul4a;Cul4a protein;CUL4A;Cullin-4A;MGC36573;MGC64071
UNIProt ID:
Q13619