CBFA2T2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-19075-20uL | 20uL | £125.00 |
Quantity:
| E-AB-19075-60uL | 60uL | £172.00 |
Quantity:
| E-AB-19075-120uL | 120uL | £237.00 |
Quantity:
| E-AB-19075-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
CBFA2T2
Background:
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
67 kDa
Concentration:
1.26 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:5000, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human CBFA2T2
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
AML1 MTG8;cbfa2t2;Core binding factor runt domain alpha subunit 2 translocated to 2;core-binding factor; runt domain; alpha subunit 2;DKFZp313F2116;EHT;ETO homolog on chromosome 20;ETO homologous on chromosome 20;MTG 8 like protein;MTG 8 related protein 1;MTG8 like protein;MTG8 related protein 1;MTG8-like protein;MTG8-related protein 1;MTG8R;MTGR 1;Myeloid translocation gene related protein 1;Myeloid translocation related protein 1;Myeloid translocation-related protein 1;p85;Protein CBFA2T2;ZMYND 3;ZMYND3
UNIProt ID:
O43439