RIC8A Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-19028-20uL | 20uL | £125.00 |
Quantity:
| E-AB-19028-60uL | 60uL | £172.00 |
Quantity:
| E-AB-19028-120uL | 120uL | £237.00 |
Quantity:
| E-AB-19028-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
RIC8A
Background:
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.96 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:300, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human RIC8A
Purification method:
Antigen affinity purification
Target Synonym:
MGC104517;MGC131931;MGC148073;MGC148074;Protein Ric-8A;resistance to inhibitors of cholinesterase 8 homolog A (C. elegans);RIC8;RIC8A;RIC8A;Synembryn-A
UNIProt ID:
Q9NPQ8