EWSR1 Polyclonal Antibody

EWSR1

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

68 kDa

1.26 mg/mL

Unconjugated

WB 1:1000-1:5000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Fusion protein of human EWSR1

Refer to figures

Antigen affinity purification

bK984G1.4;bK984G1.4 Ewing sarcoma breakpoint region 1 protein;Ewing sarcoma breakpoint region 1;Ewing sarcoma breakpoint region 1 protein;Ewings sarcoma EWS Fli1 type 1 oncogene;EWS;EWS oncogene;EWS RNA binding protein 1;EWS;EWSR 1;Ewsr1;EWSR1 protein;RNA binding protein EWS;RNA-binding protein EWS

Q01844