PNRC2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-18895-20uL | 20uL | £125.00 |
Quantity:
| E-AB-18895-60uL | 60uL | £172.00 |
Quantity:
| E-AB-18895-120uL | 120uL | £237.00 |
Quantity:
| E-AB-18895-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
PNRC2
Background:
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.54 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human PNRC2
Purification method:
Antigen affinity purification
Target Synonym:
0610011E17Rik;D4Bwg0593e;FLJ20312;MGC11707;MGC93828;MGC99541;OTTMUSP00000010360;OTTMUSP00000010366;pnrc2;PNRC2;Proline rich nuclear receptor coactivator 2;Proline-rich nuclear receptor coactivator 2;RP11-4M23.5;RP23-161N17.3
UNIProt ID:
Q9NPJ4