HUS1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-18816-20uL | 20uL | £125.00 |
Quantity:
| E-AB-18816-60uL | 60uL | £172.00 |
Quantity:
| E-AB-18816-120uL | 120uL | £237.00 |
Quantity:
| E-AB-18816-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HUS1
Background:
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.14 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:300, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human HUS1
Purification method:
Antigen affinity purification
Target Synonym:
Checkpoint protein HUS1;hHUS1;HUS1 (S. pombe) checkpoint homolog;Hus1;HUS1 checkpoint homolog (S. pombe);HUS1 Checkpoint Protein;HUS1 protein;HUS1+ - like protein;HUS1;Hydroxyurea-sensitive 1; S. pombe; homolog of
UNIProt ID:
O60921