TPMT Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-18800-20uL | 20uL | £125.00 |
Quantity:
| E-AB-18800-60uL | 60uL | £172.00 |
Quantity:
| E-AB-18800-120uL | 120uL | £237.00 |
Quantity:
| E-AB-18800-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
TPMT
Background:
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
28 kDa
Concentration:
0.96 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human TPMT
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
HGNC:12014;S adenosyl L methionine thiopurine S methyltransferase;Thiopurine methyltransferase;Thiopurine S methyltransferase;Thiopurine S-methyltransferase;TPMT;TPMT
UNIProt ID:
P51580