RNF111 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-18773-20uL | 20uL | £125.00 |
Quantity:
| E-AB-18773-60uL | 60uL | £172.00 |
Quantity:
| E-AB-18773-120uL | 120uL | £237.00 |
Quantity:
| E-AB-18773-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
RNF111
Background:
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.84 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:300, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human RNF111
Purification method:
Antigen affinity purification
Target Synonym:
ARK;Arkadia;DKFZp313E0731;DKFZp686H1966;DKFZp761D081;E3 ubiquitin protein ligase Arkadia;E3 ubiquitin-protein ligase Arkadia;FLJ38008;RING finger protein 111;RN111;RNF 111;RNF111
UNIProt ID:
Q6ZNA4