BCAS3 Polyclonal Antibody

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Elabscience
Product Code: E-AB-18703
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-18703-20uL20uL£125.00
Quantity:
E-AB-18703-60uL60uL£172.00
Quantity:
E-AB-18703-120uL120uL£237.00
Quantity:
E-AB-18703-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Immunohistochemistry of paraffin-embedded Human lung cancer tissue using BCAS3 Polyclonal Antibody at dilution of 1:35(?200)
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Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using BCAS3 Polyclonal Antibody at dilution of 1:35(?200)
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Immunohistochemistry of paraffin-embedded Human lung cancer tissue using BCAS3 Polyclonal Antibody at dilution of 1:35(?200)
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using BCAS3 Polyclonal Antibody at dilution of 1:35(?200)

Documents

Further Information

Abbreviation:
BCAS3
Background:
BCAS3 (breast carcinoma amplified sequence 3), also designated MAAB or GAOB1, is a 913 amino acid protein that is believed to be involved in breast cancer progression. The gene is regulated by ER (estrogen receptor alpha) and expressed in multiple tissues, including malignant human brain lesions. It is overexpressed and amplified in breast cancer cell lines. BCAS3 contains three WD40 repeat regions, a bromodomain, a rare zinc-finger motif, four probable DNA-binding domains, and two kinase-inducible phosphorylation domains. Five variants are produced due to alternative splicing. BCAS3 interacts with histone H3 and PCAF, which is indicative of histone acetyltransferase activity. BCAS3 also exhibits ER transactiviation activity by acting as a coactivator with PELP1 or MTA1. The amplification and translocation between the BCAS3 gene and the BCAS4 gene results in a fusion transcript is overexpressed in MCF-7 cells.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
101 kDa
Concentration:
1.26 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human BCAS3
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
1500019F07Rik;2610028P08Rik;AU021018;BC028339;BCAS3;BCAS3;Breast carcinoma-amplified sequence 3;FLJ20128;GAOB1;K20D4;MAAB;Maab1 protein;MGC4973;rudhira
UNIProt ID:
Q9H6U6