IMPA1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-18668-20uL | 20uL | £125.00 |
Quantity:
| E-AB-18668-60uL | 60uL | £172.00 |
Quantity:
| E-AB-18668-120uL | 120uL | £237.00 |
Quantity:
| E-AB-18668-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
IMPA1
Background:
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
30 kDa
Concentration:
0.9 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human IMPA1
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
IMP 1;IMP;IMPA 1;IMPA;IMPA1;IMPA1;IMPase 1;IMPase;Inositol 1(or 4) monophosphatase;Inositol monophosphatase 1;Inositol monophosphatase;Inositol(myo) 1(or 4) monophosphatase 1;Inositol-1(or 4)-monophosphatase 1;Lithium sensitive myo inositol monophosphatase A1;Lithium-sensitive myo-inositol monophosphatase A1
UNIProt ID:
P29218