RIPK1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-18284-20uL | 20uL | £125.00 |
Quantity:
| E-AB-18284-60uL | 60uL | £172.00 |
Quantity:
| E-AB-18284-120uL | 120uL | £237.00 |
Quantity:
| E-AB-18284-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
RIPK1
Background:
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
76 kDa
Concentration:
0.7 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human RIPK1
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
Cell death protein RIP;FLJ39204;OTTHUMP00000039163;Receptor (TNFRSF) interacting serine threonine kinase 1;receptor interacting protein 1;Receptor interacting protein;Receptor interacting protein kinase 1;Receptor interacting serine threonine protein kinase 1;Receptor TNFRSF interacting serine threonine kinase 1;Receptor-interacting protein 1;Receptor-interacting serine/threonine-protein kinase 1;Rinp;RIP 1;RIP;Rip-1;RIP1;RIPK 1;Ripk1;RIPK1;Serine threonine protein kinase RIP;Serine/threonine-protein kinase RIP
UNIProt ID:
Q13546