BAG3 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-18208-20uL | 20uL | £125.00 |
Quantity:
| E-AB-18208-60uL | 60uL | £172.00 |
Quantity:
| E-AB-18208-120uL | 120uL | £237.00 |
Quantity:
| E-AB-18208-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
BAG3
Background:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
62 kDa
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human BAG3
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
BAG 3;BAG family molecular chaperone regulator 3;BAG-3;Bag3;BAG3;Bcl 2 binding protein;Bcl-2-associated athanogene 3;Bcl-2-binding protein Bis;BCL2 associated athanogene 3;BCL2 binding athanogene 3;BIS;CAIR 1;Docking protein CAIR 1;Docking protein CAIR-1;MFM6
UNIProt ID:
O95817