CASP1 Polyclonal Antibody

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Elabscience
Product Code: E-AB-18207
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-18207-20uL20uL£125.00
Quantity:
E-AB-18207-60uL60uL£172.00
Quantity:
E-AB-18207-120uL120uL£237.00
Quantity:
E-AB-18207-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western blot analysis of Hela cells using CASP1 Polyclonal Antibody at dilution of 1:1000
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Immunohistochemistry of paraffin-embedded Human pancre at ic cancer tissue using CASP1 Polyclonal Antibody at dilution of 1:25(?200)
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Western blot analysis of Hela cells using CASP1 Polyclonal Antibody at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Human pancre at ic cancer tissue using CASP1 Polyclonal Antibody at dilution of 1:25(?200)

Documents

Further Information

Abbreviation:
CASP1
Background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
45 kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:4000, IHC 1:25-1:100, ELISA 1:1000-1:10000
Immunogen:
Fusion protein of human CASP1
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
CASP-1;CASP1;CASP1;Caspase 1;Caspase-1 subunit p10;ICE;IL-1 beta-converting enzyme;IL-1BC;IL1 beta converting enzyme;IL1B convertase;Interleukin 1 beta convertase;Interleukin 1B converting enzyme;Interleukin-1 beta convertase;Interleukin-1 beta-converting enzyme;p45
UNIProt ID:
P29466

References

  • https://www.sciencedirect.com/science/article/pii/S002432052030816X