HLA-DRB3 Polyclonal Antibody

Contact us
Elabscience
Product Code: E-AB-18084
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-18084-20uL20uL£125.00
Quantity:
E-AB-18084-60uL60uL£172.00
Quantity:
E-AB-18084-120uL120uL£237.00
Quantity:
E-AB-18084-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

1 / 1
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using HLA-DRB3 Polyclonal Antibody at dilution of 1:50(?200)
❮❯

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using HLA-DRB3 Polyclonal Antibody at dilution of 1:50(?200)

Documents

Further Information

Abbreviation:
HLA-DRB3
Background:
HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.44 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:20-1:100, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human HLA-DRB3
Purification method:
Antigen affinity purification
Target Synonym:
DR beta 3 chain;DR7;DRB3;HLA class II histocompatibility antigen;HLA class II histocompatibility antigen DR beta 3 chain;HLA class II histocompatibility antigen DRB1 7 beta chain;HLA DR3B;HLA-DRB3;Human leucocyte antigen DRB3;Major histocompatibility complex class II DR beta 3;MGC117330;MHC class II antigen DR beta 3 chain;MHC class II antigen DRB3;MHC class II HLA DR beta 3 chain
UNIProt ID:
P79483