HLA-C Polyclonal Antibody
Code | Size | Price |
---|
E-AB-17922-20uL | 20uL | £125.00 |
Quantity:
E-AB-17922-60uL | 60uL | £172.00 |
Quantity:
E-AB-17922-120uL | 120uL | £237.00 |
Quantity:
E-AB-17922-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Images
Further Information
Abbreviation:
HLA-C
Background:
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described .
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.66 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:25-1:100, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human HLA-C
Purification method:
Antigen affinity purification
Target Synonym:
HLA-JY3;D6S204;HLAC;Psoriasis Susceptibility 1;HLA-C Alpha Chain;PSORS1;MHC
UNIProt ID:
P10321
References
- https://www.nature.com/articles/s41598-022-12870-6