HLA-B Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-17921-20uL | 20uL | £125.00 |
Quantity:
| E-AB-17921-60uL | 60uL | £172.00 |
Quantity:
| E-AB-17921-120uL | 120uL | £237.00 |
Quantity:
| E-AB-17921-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HLA-B
Background:
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
40 kDa
Concentration:
0.9 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human HLA-B
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
1B07;AS;B-4901;B-7 alpha chain;HC class I antigen SHCHA;HLA class I histocompatibility antigen;HLA class I histocompatibility antigen; B alpha chain;HLA-B;HLA-B histocompatibility type;HLAB;leukocyte antigen class I-B;major histocompatibility complex; class I; B;MHC class 1 antigen;MHC class I antigen B*7;MHC class I antigen HLA-B alpha chain;MHC class I antigen HLA-B heavy chain;MHC Class I HLA heavy chain;MHC class I molecule;MHC HLA-B cell surface glycoprotein;MHC HLA-B transmembrane glycoprotein;SPDA1
UNIProt ID:
P01889