IL17A Polyclonal Antibody
Code | Size | Price |
---|
E-AB-17917-20uL | 20uL | £125.00 |
Quantity:
E-AB-17917-60uL | 60uL | £172.00 |
Quantity:
E-AB-17917-120uL | 120uL | £237.00 |
Quantity:
E-AB-17917-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Images
Further Information
Abbreviation:
IL17A
Background:
IL17A,also named as IL-17,is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells,has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.14 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human IL17A
Purification method:
Antigen affinity purification
Target Synonym:
CTLA 8;CTLA-8;CTLA8;Cytotoxic T lymphocyte associated antigen 8;Cytotoxic T lymphocyte associated protein 8;Cytotoxic T lymphocyte associated serine esterase 8;Cytotoxic T-lymphocyte-associated antigen 8;IL 17A;IL-17;IL-17A;IL17;IL17;Il17a;Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8);Interleukin 17A;Interleukin-17A;Interleukin17;Interleukin17A;OTTHUMP00000016597;OTTMUSP00000046003
UNIProt ID:
Q16552