DROSHA Polyclonal Antibody

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Elabscience
Product Code: E-AB-17893
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-17893-20uL20uL£125.00
Quantity:
E-AB-17893-60uL60uL£172.00
Quantity:
E-AB-17893-120uL120uL£237.00
Quantity:
E-AB-17893-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using DROSHA Polyclonal Antibody at dilution of 1:45(?200)
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Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using DROSHA Polyclonal Antibody at dilution of 1:45(?200)

Documents

Further Information

Abbreviation:
DROSHA
Background:
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. DROSHA (Drosha Ribonuclease III) is a Protein Coding gene. Diseases associated with DROSHA include Combat Disorder and Murray Valley Encephalitis. Among its related pathways are mRNA Capping and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and RNA binding.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.74 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human DROSHA
Purification method:
Antigen affinity purification
Target Synonym:
DROSHA;Drosha double stranded RNA specific endoribonuclease;Drosha ribonuclease type III;Etohi2;HSA242976;Nuclear RNase III Drosha;p241;Protein Drosha;Putative protein p241 which interacts with transcription factor Sp1;Putative ribonuclease III;RANSE3L;Ribonuclease 3;Ribonuclease III;Ribonuclease III nuclear;Ribonuclease type III nuclear;RibonucleaseIII;RN 3;RN3;RNase 3;RNase III;RNase3;RNASE3L;RNaseIII;RNASEN;RNC
UNIProt ID:
Q9NRR4