CGAS Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-17843-20uL | 20uL | £125.00 |
Quantity:
| E-AB-17843-60uL | 60uL | £172.00 |
Quantity:
| E-AB-17843-120uL | 120uL | £237.00 |
Quantity:
| E-AB-17843-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
CGAS
Background:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
59 kDa
Concentration:
0.78 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human MB21D1
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
C6orf150;cGAMP synthase;cGAS;CGAS;cGMP Synthase;Chromosome 6 open reading frame 150;Cyclic GMP-AMP synthase;h-cGAS;Hypothetical protein LOC115004;Mab 21 domain containing 1;Mab-21 domain-containing protein 1;MB21D1;MGC131892;MGC142166;MGC142168;OTTHUMP00000016743;OTTHUMP00000039330;protein MB21D1;Uncharacterized protein C6orf150
UNIProt ID:
Q8N884