CARD16 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-17810-20uL | 20uL | £125.00 |
Quantity:
| E-AB-17810-60uL | 60uL | £172.00 |
Quantity:
| E-AB-17810-120uL | 120uL | £237.00 |
Quantity:
| E-AB-17810-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
CARD16
Background:
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
23 kDa
Concentration:
1.1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human CARD16
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
CAR16;CARD only domain-containing protein 1;CARD only protein ;CARD16;Caspase recruitment domain family; member 16;Caspase recruitment domain-containing protein 16;Caspase-1 dominant-negative inhibitor pseudo-ICE ;Caspase-1 inhibitor COP;COP;COP1;Pseudo interleukin 1 beta converting enzyme;Pseudo interleukin-1 beta converting enzyme;Pseudo interleukin-1beta converting enzyme ;PSEUDO-ICE
UNIProt ID:
Q5EG05