CACNA2D2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-17757-20uL | 20uL | £125.00 |
Quantity:
| E-AB-17757-60uL | 60uL | £172.00 |
Quantity:
| E-AB-17757-120uL | 120uL | £237.00 |
Quantity:
| E-AB-17757-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
CACNA2D2
Background:
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.7 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human CACNA2D2
Purification method:
Antigen affinity purification
Target Synonym:
Alpha 2 delta calcium channel subunit;CA2D2;CACNA2D;Cacna2d2;Calcium channel;voltage-dependent;alpha 2/delta subunit 2;Calcium channel;voltage-dependent;alpha 2/delta subunit 2 gene 26;Calcium voltage gated channel auxiliary subunit alpha2delta 2;Gene 26;KIAA0558;LUAC11.1;Voltage-dependent calcium channel subunit alpha-2/delta-2;Voltage-dependent calcium channel subunit delta-2;Voltage-gated calcium channel subunit alpha-2/delta-2
UNIProt ID:
Q9NY47