Recombinant Cynomolgus PD-L1/B7-H1/CD274 Protein (Fc Tag)
| Code | Size | Price |
|---|
| PKSQ050046-10ug | 10ug | £166.00 |
Quantity:
| PKSQ050046-50ug | 50ug | £315.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Monkey
Regulatory Status: RUO
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Further Information
Abbreviation:
PD-L1;B7-H1;CD274
Accession:
G7PSE7
Background:
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
Calculated MW:
52.4 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS,pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc
ObservedMW:
73 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Phe19-Thr239
Target Synonym:
B7-H;B7H1;B7-H1;B7H1PDCD1L1;CD274 antigenMGC142294;CD274 molecule;CD274;PDCD1L1;PDCD1LG1;PDL1;PD-L1;PD-L1B7 homolog 1;PDL1PDCD1 ligand 1;programmed cell death 1 ligand 1;Programmed death ligand 1
UNIProt ID:
G7PSE7