Recombinant Cynomolgus LAG-3/CD223 Protein (His Tag)
| Code | Size | Price |
|---|
| PKSQ050011-10ug | 10ug | £248.00 |
Quantity:
| PKSQ050011-50ug | 50ug | £380.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Monkey
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Further Information
Abbreviation:
LAG-3;CD223
Accession:
XP_005570011.1
Activity:
Immobilized Cynomolgus LAG-3-His at 2ug/ml(100 ul/well) can bind Human FGL1-Fc. The ED50 of Cynomolgus LAG-3-His is 5. 8 ug/ml.
Background:
Lymphocyte Activating 3(LAG3) belongs to immunoglobulin (Ig) superfamily, Macaca fascicularis LAG3 cDNA encodes 533 amino acids (aa) that include a 17 aa signal sequence, a 451 aa extracellular domain (ECD) with two Ig-like domains, a transmembrane region and a highly charged cytoplasmic region. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function.
Calculated MW:
47.3 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS,PH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-His
ObservedMW:
55-65&140 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Pro23-Leu450(Pro74)
Target Synonym:
Lymphocyte Activating 3;LAG3;LAG-3;CD223