Recombinant Human CD226/DNAM-1 Protein (Fc Tag)(Active)
| Code | Size | Price |
|---|
| PKSH033729-10ug | 10ug | £150.00 |
Quantity:
| PKSH033729-50ug | 50ug | £292.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Further Information
Abbreviation:
CD226;DNAM-1
Accession:
Q15762
Activity:
Immobilized Human DNAM-1-Fc at 2ug/ml(100 ul/well) can bind Human Nectin-2-6His(Cat: PKSH032913). The ED50 of Human DNAM-1-Fc is 0.79 ug/mL
Background:
Human DNAX accessory molecule 1 (DNAM-1/CD226) is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. Mature human DNAM-1 contains an extracellular domain (ECD) with two Ig-like C2-set domains and a cytoplasmic region that contains motifs for binding PDZ domains and band 4.1 family proteins. DNAM-1 is expressed on multiple lymphoid and myeloid cells and interacts with CD155 and CD112. Ligation of DNAM-1 promotes the activation of NK cells; CD8+ T cells; and mast cells; dendritic cell maturation; megakaryocyte and activated platelet adhesion to vascular endothelial cells; and monocyte extravasation; it inhibits the forrmation of osteoclasts. Plateletendothelium; interactions mediated by DNAM-1; enable the metastasis of tumor cells to the lung.
Calculated MW:
52.8 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc
ObservedMW:
72-90 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Glu19-Asn247
Target Synonym:
CD226 antigen;DNAX accessory molecule 1;DNAM-1;CD226;DNAM1
UNIProt ID:
Q15762