Biotin Anti-Mouse CD274/PD-L1 Antibody[10F.9G2]
Code | Size | Price |
---|
E-AB-F1132B-25ug | 25ug | £101.00 |
Quantity:
E-AB-F1132B-100ug | 100ug | £131.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2b, κ
Antibody Clone: 10F.9G2
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
Ice packs
Storage:
Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Further Information
Abbreviation:
CD274/PD-L1
Background:
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Concentration:
0.5 mg/mL
Conjugation:
Biotin
GeneID:
60533
Target Synonym:
B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
UNIProt ID:
Q9EP73
Usage:
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is < 1.0 ug per 10^6 cells in 100 uL volume or 100 uL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
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