PE/Cyanine5 Anti-Human CD49d Antibody[9F10]
| Code | Size | Price |
|---|
| E-AB-F1144G-20Tests | 20Tests | £136.00 |
Quantity:
| E-AB-F1144G-100Tests | 100Tests | £237.00 |
Quantity:
| E-AB-F1144G-100Testsx2 | 100Testsx2 | £317.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, κ
Antibody Clone: 9F10
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
Ice packs
Storage:
Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Further Information
Abbreviation:
CD49d
Background:
CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.
Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Concentration:
5 uL/Test
Conjugation:
PE/Cyanine5
GeneID:
3676
Target Synonym:
Integrin alpha-4;CD49 antigen-like family member D;Integrin alpha-IV;VLA-4 subunit alpha;CD49d;ITGA4;
UNIProt ID:
P13612
Usage:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 uL staining volume or per 100 uL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.