AF/LE Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3]
Code | Size | Price |
---|
E-AB-F11330-50ug | 50ug | £140.00 |
Quantity:
E-AB-F11330-500ug | 500ug | £341.00 |
Quantity:
E-AB-F11330-1mg | 1mg | £475.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG2b, κ
Antibody Clone: 29E.2A3
Regulatory Status: RUO
Target Species: Human
Applications:
- Blocking
- Flow Cytometry
- Functional Study
Shipping:
Ice packs
Storage:
Store at 2-8°C. Do not freeze.
Further Information
Abbreviation:
PD-L1
Background:
CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
Buffer:
0.2 um filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Concentration:
0.5 mg/mL
Conjugation:
None (Purified antibody-Azide Free/Low endotoxin)
GeneID:
29126
Target Synonym:
B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
UNIProt ID:
Q9NZQ7
Usage:
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is < 0.5 ug per 10^6 cells in 100 uL volume or 100 uL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
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