BRCA2 Polyclonal Antibody

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Elabscience
Product Code: E-AB-40288
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-40288-20uL20uL£120.00
Quantity:
E-AB-40288-60uL60uL£160.00
Quantity:
E-AB-40288-120uL120uL£230.00
Quantity:
E-AB-40288-200uL200uL£331.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western Blot analysis of Hela cells using BRCA2 Polyclonal Antibody at dilution of 1:2000
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Immunohistochemistry of paraffin-embedded Human colon using BRCA2 Polyclonal Antibody at dilution of 1:100
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Immunofluorescence analysis of U-2OS cells using BRCA2 Polyclonal Antibody at dilution of 1:100
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Immunofluorescence analysis of U-251MG cells using BRCA2 Polyclonal Antibody at dilution of 1:100
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Western Blot analysis of Hela cells using BRCA2 Polyclonal Antibody at dilution of 1:2000
Immunohistochemistry of paraffin-embedded Human colon using BRCA2 Polyclonal Antibody at dilution of 1:100
Immunofluorescence analysis of U-2OS cells using BRCA2 Polyclonal Antibody at dilution of 1:100
Immunofluorescence analysis of U-251MG cells using BRCA2 Polyclonal Antibody at dilution of 1:100

Documents

Further Information

Abbreviation:
BRCA2
Background:
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Buffer:
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Calculated MW:
384 kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:3000 IHC 1:100-1:200 IF 1:100-1:400
Immunogen:
Recombinant Human Breast cancer type 2 susceptibility protein
ObservedMW:
384 kDa
Purification method:
Antigen Affinity Purification
Target Synonym:
BRCA 2; BRCC 2; Breast and ovarian cancer susceptibility gene early onset antibody; BROVCA2; FACD; FAD 1; FANCB; GLM3
UNIProt ID:
P51587