ZBTB33 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-64352-60uL | 60uL | £210.00 |
Quantity:
| E-AB-64352-120uL | 120uL | £291.00 |
Quantity:
| E-AB-64352-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
ZBTB33
Background:
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
74kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:3000
Immunogen:
Recombinant fusion protein of human ZBTB33 (NP_006768.1).
ObservedMW:
74kDa
Purification method:
Affinity purification
Target Synonym:
ZBTB33;ZNF-kaiso;ZNF348
UNIProt ID:
Q86T24