SMAD7 Polyclonal Antibody

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Elabscience
Product Code: E-AB-63686
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-63686-60uL60uL£210.00
Quantity:
E-AB-63686-120uL120uL£291.00
Quantity:
E-AB-63686-200uL200uL£431.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western blot analysis of extracts of various cell lines using SMAD7 Polyclonal Antibody at dilution of 1:1000.
2 / 2
Immunofluorescence analysis of U2OS cells using SMAD7 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
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Western blot analysis of extracts of various cell lines using SMAD7 Polyclonal Antibody at dilution of 1:1000.
Immunofluorescence analysis of U2OS cells using SMAD7 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

Documents

Further Information

Abbreviation:
SMAD7
Background:
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
23kDa/46kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000 IF 1:50-1:200
Immunogen:
A synthetic peptide of human SMAD7 (NP_005895.1).
ObservedMW:
46kDa
Purification method:
Affinity purification
Target Synonym:
SMAD7;CRCS3;MADH7;MADH8
UNIProt ID:
O15105