SIRT1 Polyclonal Antibody
Code | Size | Price |
---|
E-AB-70071-60uL | 60uL | £184.00 |
Quantity:
E-AB-70071-120uL | 120uL | £251.00 |
Quantity:
E-AB-70071-200uL | 200uL | £351.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Images
Further Information
Abbreviation:
SIRT1
Background:
SIRT1,also named as SIR2L1,contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. It regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signalling events relevant to cardioprotection,including: activation of endothelial nitric oxide synthase,insulin receptor signalling,and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO,Hif-2a,and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53,specifically at Lysine 382.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration:
0.57 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:200-1:800
Immunogen:
KLH conjugated Synthetic peptide corresponding to Mouse SIRT1
Purification method:
Affinity purification
Target Synonym:
75SirT1;hSIR2;hSIRT1;HST2;S. cerevisiae;homolog of;NAD dependent deacetylase sirtuin 1;NAD dependent protein deacetylase sirtuin 1;OTTHUMP00000198111;OTTHUMP00000198112;Regulatory protein SIR2 homolog 1;SIR1;SIR2;SIR2 like 1;SIR2 like protein 1;SIR2;S.cerevisiae;homolog-like 1;SIR2-like protein 1;SIR2ALPHA;SIR2L1;Sirt1;SirtT1 75 kDa fragment;Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);Sirtuin 1;Sirtuin type 1
UNIProt ID:
Q96EB6,Q923E4,Q96EB6,
References
- https://link.springer.com/article/10.1007/s10571-019-00710-7