SHC1 Polyclonal Antibody

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Elabscience
Product Code: E-AB-62212
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-62212-60uL60uL£210.00
Quantity:
E-AB-62212-120uL120uL£291.00
Quantity:
E-AB-62212-200uL200uL£431.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Documents

Further Information

Abbreviation:
SHC1
Background:
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200 IF 1:50-1:200
Immunogen:
A synthetic peptide of human SHC1
Purification method:
Affinity purification
Target Synonym:
SHC;SHCA;SHC1
UNIProt ID:
P29353