RUNX2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-62026-60uL | 60uL | £210.00 |
Quantity:
| E-AB-62026-120uL | 120uL | £291.00 |
Quantity:
| E-AB-62026-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
RUNX2
Background:
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
54kDa/55kDa/56kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:200-1:1000
Immunogen:
Recombinant fusion protein of human RUNX2 (NP_001019801.3).
ObservedMW:
70kDa
Purification method:
Affinity purification
Target Synonym:
RUNX2;AML3;CBF-alpha-1;CBFA1;CCD;CCD1;CLCD;OSF-2;OSF2;PEA2aA;PEBP2aA
UNIProt ID:
Q13950