ROCK1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-70124-60uL | 60uL | £184.00 |
Quantity:
| E-AB-70124-120uL | 120uL | £251.00 |
Quantity:
| E-AB-70124-200uL | 200uL | £351.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
ROCK1
Background:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration:
300 ug/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:100-1:400
Immunogen:
KLH conjugated Synthetic peptide corresponding to Mouse Rock1
Purification method:
Affinity purification
Target Synonym:
coiled-coil-containing protein kinase 1;coiled-coil-containing protein kinase I;MGC131603;MGC43611;p160 Rhoassociated coiled coil-forming protein kinase;p160 ROCK-1;p160 ROCK1;p160ROCK;PRO0435;Renal carcinoma antigen NY REN 35;Renal carcinoma antigen NY-REN-35;Rho associated coiled coil containing protein kinase 1;Rho associated protein kinase 1;Rho kinase;Rho-alpha kinase;Rho-associated;Rho-associated protein kinase 1;ROCK I;ROCK-I;ROCK1;ROCK1;Rok;rokalpha
UNIProt ID:
P70335,Q63644