Purified Anti-Human/Mouse/Rat CD47 Antibody[MIAP410]

CD47

CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.

0.5 mg/mL

Unconjugated

9,611,642,329,364

Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;

Q08722;Q61735;P97829;

Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is < 2.0 ug per 10^6 cells in 100 uL volume or 100 uL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.