PSEN1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-60669-60uL | 60uL | £210.00 |
Quantity:
| E-AB-60669-120uL | 120uL | £291.00 |
Quantity:
| E-AB-60669-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
PSEN1
Background:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
21kDa/42kDa/46kDa/48kDa/52kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000 IHC 1:50-1:200
Immunogen:
Recombinant fusion protein of human PSEN1 (NP_015557.2).
ObservedMW:
52kDa
Purification method:
Affinity purification
Target Synonym:
AD3;FAD;PS-1;PS1;S182;Presenilin 1;PSEN1
UNIProt ID:
P49768