PPARA Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-70253-60uL | 60uL | £184.00 |
Quantity:
| E-AB-70253-120uL | 120uL | £251.00 |
Quantity:
| E-AB-70253-200uL | 200uL | £351.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
PPARA
Background:
Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid β-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-κB, causing inhibition of its signaling pathway or reducing the activated levels of NF-κB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:200-1:500
Immunogen:
KLH conjugated Synthetic peptide corresponding to Mouse PPARα
Purification method:
Affinity purification
Target Synonym:
hPPAR;MGC2237;MGC2452;NR1C1;Nuclear receptor subfamily 1 group C member 1;OTTHUMP00000197740;OTTHUMP00000197741;Peroxisome proliferative activated receptor alpha;Peroxisome proliferator activated receptor alpha;Peroxisome proliferator-activated receptor alpha;PPAR;PPAR-alpha;ppara;PPARA;PPARalpha
UNIProt ID:
P23204,P37230