PHF19 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-62410-60uL | 60uL | £210.00 |
Quantity:
| E-AB-62410-120uL | 120uL | £291.00 |
Quantity:
| E-AB-62410-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunofluorescence (IF)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
PHF19
Background:
Polycomb group (PcG protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3 and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2. Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Calculated MW:
14kDa/22kDa/65kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IF 1:50-1:100
Immunogen:
Recombinant fusion protein of human PHF19
ObservedMW:
66kDa
Purification method:
Affinity purification
Target Synonym:
PHF19;MTF2L1;PCL3;TDRD19B
UNIProt ID:
Q5T6S3