PDE6B Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-61419-60uL | 60uL | £210.00 |
Quantity:
| E-AB-61419-120uL | 120uL | £291.00 |
Quantity:
| E-AB-61419-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
PDE6B
Background:
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:100
Immunogen:
Recombinant fusion protein of human PDE6B (NP_001138763.1).
Purification method:
Affinity purification
Target Synonym:
PDE6B;CSNB3;CSNBAD2;PDEB;RP40;rd1;GMP-PDEbeta
UNIProt ID:
P35913